Interleukin-27 inhibits phagosomal acidification by blocking vacuolar ATPases
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چکیده
منابع مشابه
Proton ATPases and urinary acidification.
Acidification of the urine is mediated by vectorial H+ transport from cells at a number of sites in the kidney. A proton ATPase has been described that appears to mediate a significant proportion of this H+ transport. In particular, in proximal tubule and collecting duct, there is evidence both for the presence of transporter protein and for H+ transport with features that have been identified ...
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Phagocytosis holds a central position in the development of a successful innate immune response and in the initiation of the corresponding adaptive response. The destruction of invading pathogens and the presentation of their antigens to lymphoid cells require acidification of the phagosomal lumen. The present review discusses the mechanism of phagosome acidification, with particular reference ...
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It was reported recently that the cystic fibrosis conductance regulator protein (CFTR) is required for acidification of phagosomes in alveolar macrophages (Di et al. Nature Cell Biol. 8:933–944, 2006). Here we determined whether the CFTR chloride channel is a generalized pathway for chloride entry into phagosomes of macrophages and whether mutations in CFTR could contribute to alveolar macropha...
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Bioenergetics and physiology of primary pumps have been revitalized by new insights into the mechanism of energizing biomembranes. Structural information is becoming available, and the three-dimensional structure of F-ATPase is being resolved. The growing understanding of the fundamental mechanism of energy coupling may revolutionize our view of biological processes. The F- and V-ATPases (vacuo...
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ژورنال
عنوان ژورنال: Cytokine
سال: 2013
ISSN: 1043-4666
DOI: 10.1016/j.cyto.2013.03.010